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Recent developments in genomic and communication technologies are prompting shifts in the social, institutional and ethical architectures of biomedicine. Examples include direct-to-consumer genetic testing and crowd-sourced, “citizen-science” epidemiological research using smartphones and the web. These new architectures promise a gold rush of information and biospecimens that may provide a foundation for a more precise, personalized, and targeted medicine. They are also attracting new actors and new modes of participation that have the potential to enhance but also to destabilize established patterns of ethical, legal, and social responsibilities in biomedicine. How will these changing patterns of research and discovery affect citizens, consumers, donors, patients, physicians, researchers, and companies? This event, combining a public lecture and one-day workshop, explores these questions with a group of leaders spanning the biomedical sciences and engineering, social sciences, humanities, and industry