PLOS Medicine
Vol. 22, Issue 12
Date of Publication:
December 2025
This observational study examines global differences in life expectancy through the lens of sex inequalities rather than biological sex differences alone. Using cross-country benchmarking analysis, the authors evaluate how social, economic, and health-system factors shape disparities in mortality outcomes between women and men across countries. The findings suggest that many observed life expectancy gaps reflect avoidable inequalities linked to gendered social conditions and health system performance, highlighting opportunities for policy interventions to improve population health equity.
Citations
Chang AY, Johnson EK, Bolongaita S, Buse K, Hawkes SJ, Karlsson O, Knaul FM, Kruk ME, Norheim OF, Ogbuoji O, Watkins D, Jamison DT. From sex differences to sex inequalities in life expectancy: a cross-country observational benchmarking analysis. PLoS Med. 2025 Dec 11;22(12):e1004828. doi:10.1371/journal.pmed.1004828.