Single-dose HPV vaccination in the United States – a multi-modeling analysis

his study uses two validated simulation models of HPV transmission and cervical cancer to evaluate the long-term impact of switching from a two-dose to a single-dose HPV vaccination schedule in the United States. Results suggest that a single-dose strategy could maintain substantial reductions in HPV infections and cervical cancer incidence—potentially reducing cervical cancer by over 90%—even under less optimistic assumptions about vaccine efficacy and duration, supporting its viability as a policy option.