Rates of major depressive symptoms are elevated after acute infection with SARS-CoV-2.1-3 A key question is whether such symptoms represent a general consequence of stress associated with acute illness or whether they reflect more specific sequelae associated with COVID-19 pathophysiology itself. To examine this possibility, in this survey study, we compared features of major depression in individuals with or without prior COVID-19 illness.
Perlis, Roy H., Jon Green, Katherine Ognyanova, Mauricio Santillana, James Druckman, David Lazer, and Matthew A. Baum. "Factors Associated With Self-reported Symptoms of Depression Among Adults With and Without a Previous COVID-19 Diagnosis." JAMA Network Open 4.6 (June 2021).